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Biology Homework Help – Evaluate the role of the p53 protein in tumour suppression and assess the consequences of TP53 mutations in individuals with Li Fraumeni Syndrome

1. Evaluate the role of the p53 protein in tumour suppression and assess the consequences of TP53 mutations in individuals with Li Fraumeni Syndrome.
2. Discuss the importance of mutations in APC in the initiation of colorectal cancer and assess the consequences of germ line mutations in individuals with familial adenomatous polyposis (FAP). Include molecular details of the Wnt signalling pathway in your answer.
3. Discuss the mechanisms that operate in the normal process of apoptosis, and review how cancer cells evade apoptotic death.
4. “Understanding of the molecular basis of cancer has led to the development of novel therapeutic agents.” Discuss this statement using two named cancers to illustrate your answer.

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Human Biochemistry: Describe the key stages in digestion and absorption of carbohydrates

Question 1

a) Describe the key stages in digestion and absorption of carbohydrates.
b) Explain the effect on carbohydrate digestion/ absorption if a patient had
i) stopped producing the enzyme lactase.
ii) a section of the duodenum removed surgically due to cancer.

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Question 2
a) DEFINE hunger and EXPLAIN how it is affected by events in the digestive system.
b) EXPLAIN how leptin acts to control body fat levels.
c) What effect will a mutation in the leptin gene (that reduces levels of this hormone) have in a human child? What could be done to treat the child?

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Question 3
Discuss how blood glucose homeostasis is maintained by the action of insulin, and glucagon.
(Your answer should encompass both the differing responses in different organs and how ...

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