Category Cancer Biology Assignments

Haematology and Immunology – Describe how bleeding and clotting disorders in haemostasis are diagnosed in the laboratory

Question 1

a) Describe how bleeding and clotting disorders in haemostasis are diagnosed in the laboratory.
b) How and why is a patient on Warfarin therapy monitored in the laboratory. How does Warfarin cause it’s effect?
c) Give an example of how the International Normalised Ratio (INR) is calculated if the prothrombin time (PT) was 25 secs, the mean normal time was 10 secs and the International Sensitivity Index (ISI) was 1.05.

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Question 2

An elderly Caucasian patient presents with shortness of breath and tiredness. Their Full Blood Count, (FBC) indicates that they have a microcytic anaemia .
a) What would the data from the FBC results be likely to show?
b) What other investigations could be performed to aid diagnosis and what morphological features might a ...

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Biology Homework Help – Evaluate the role of the p53 protein in tumour suppression and assess the consequences of TP53 mutations in individuals with Li Fraumeni Syndrome

1. Evaluate the role of the p53 protein in tumour suppression and assess the consequences of TP53 mutations in individuals with Li Fraumeni Syndrome.
2. Discuss the importance of mutations in APC in the initiation of colorectal cancer and assess the consequences of germ line mutations in individuals with familial adenomatous polyposis (FAP). Include molecular details of the Wnt signalling pathway in your answer.
3. Discuss the mechanisms that operate in the normal process of apoptosis, and review how cancer cells evade apoptotic death.
4. “Understanding of the molecular basis of cancer has led to the development of novel therapeutic agents.” Discuss this statement using two named cancers to illustrate your answer.

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